Designed especially for neurobiologists, FluoRender is an interactive tool for multi-channel fluorescence microscopy data visualization and analysis.
Deep brain stimulation
BrainStimulator is a set of networks that are used in SCIRun to perform simulations of brain stimulation such as transcranial direct current stimulation (tDCS) and magnetic transcranial stimulation (TMS).
Developing software tools for science has always been a central vision of the SCI Institute.

Events on November 28, 2017

Luis Lujan

Luis Lujan, Mayo Clinic Presents:

Electrochemical and optical techniques for understanding changes in neural activity during deep brain stimulation

November 28, 2017 at 12:30pm for 1hr
CNC 1st Floor Auditorium

Dr. Lujan is interested in using DBS and other neuromodulation techniques to restore neural function in patients with neurological injury and disease. Dr. Lujan develops and applies engineering, mathematical and computational principles and techniques to study, model and control biophysical mechanisms responsible for the motor, cognitive and affective components underlying neural activity in brain injury and disease. Additionally, he applies these models and control strategies to the development of novel clinically effective neural prostheses and brain-machine interfaces. He received his Bachelor of Science in Computer Engineering and Systems Engineering from the Universidad Autonoma de Chihuahua, a Master of Science in Biomedical Engineering and his PhD in Biomedical Engineering from Case Western Reserve University. He completed a Post Doctoral Fellowship in Deep Brain Stimulation at the Cleveland Clinic, Lerner Research Institute, Department of Biomedical Engineering.

Abstract:

Despite more than 20 years of clinical application, progress in deep brain stimulation (DBS) to treat symptoms associated with Parkinson's Disease (PD) and other neurologic disorders has been hindered by a limited understanding of the neurophysiological mechanisms underlying therapeutic effects. Mathematical modeling and electrophysiological monitoring have provided insight into the local effects of electrical stimulation on neural tissue. Additionally, functional imaging studies have revealed system-level effects on neural activity across brain regions. However, these techniques fail to bridge the gap between these disparate measurement scales. Thus, it is clear that elucidating the therapeutic mechanisms of DBS will require the application of new analysis methods that provide information on neural activity at both the cellular- and systems-level. This presentation will describe a multidisciplinary bioengineering approach that integrates DBS, electrochemical measurements, fluorescent microscopy, and computational models to characterize changes in neural activity evoked by DBS in a freely moving animal model of PD. In turn, this will enable a deeper understanding of neural activity underlying disease and therapy that can be used to improve the efficacy of DBS.

Posted by: Nathan Galli