@article{mercer_mu-8:_2014,
	title = {Mu-8: visualizing differences between proteins and their families},
	volume = {8},
	copyright = {2014 Mercer et al.; licensee {BioMed} Central Ltd.},
	issn = {1753-6561},
	shorttitle = {Mu-8},
	url = {http://www.biomedcentral.com/1753-6561/8/S2/S5/abstract},
	doi = {10.1186/1753-6561-8-S2-S5},
	abstract = {A complete understanding of the relationship between the amino acid sequence and resulting protein function remains an open problem in the biophysical sciences. Current approaches often rely on diagnosing functionally relevant mutations by determining whether an amino acid frequently occurs at a specific position within the protein family. However, these methods do not account for the biophysical properties and the 3D structure of the protein. We have developed an interactive visualization technique, Mu-8, that provides researchers with a holistic view of the differences of a selected protein with respect to a family of homologous proteins. Mu-8 helps to identify areas of the protein that exhibit: (1) significantly different bio-chemical characteristics, (2) relative conservation in the family, and (3) proximity to other regions that have suspect behavior in the folded protein.},
	language = {en},
	number = {Suppl 2},
	urldate = {2014-09-08},
	journal = {{BMC} Proceedings},
	author = {Mercer, Johnathan D. and Pandian, Balaji and Lex, Alexander and Bonneel, Nicolas and Pfister, Hanspeter},
	month = aug,
	year = {2014},
	pages = {S5}
	}