Case 1

Initial Presentation: A ##-year-old male/female was admitted for a cesarean section and immediately post-operatively developed a fever. ....Founded two years ago by a pair of computer science professors at Stanford University, Coursera enrolls seven million people in hundreds of free massive open online courses, or MOOCs, from more than 100 partner universities in 19 countries. Mr. Levin, who has been an adviser to Coursera since January, has been experimenting with online education for years, beginning in 2000 in a partnership with Stanford and Oxford. In 2007, he started Open Yale Courses to make dozens of classes taught by Yale professors available without cost..

Clinical Follow-up: The patient received dasatinib, HyperCVAD, and intrathecal methotrexate and cytarabine. ....Most of Coursera’s students are over 30, and are using the courses either for personal fulfillment or to improve their job skills. Only 15 percent are enrolled in four-year colleges. But MOOCs are evolving rapidly: Coursera recently introduced several “specializations,” a series of related courses costing $250 to $500 in which students can earn a certificate that the company believes will be valued by employers.

Bone marrow biopsy; B5-fixed and decalcified following fixation; specimen measured 2.8 x 0.2 cm grossly

For all the opportunities they have opened overseas, MOOCs have been controversial at American universities. Some professors say that such courses will widen the gap between elite colleges and others, turning a few professors at prestigious institutions into superstars while reducing faculty at second-tier schools that adopt the courses to glorified teaching assistants. There is also a worry that some professors could lose their jobs.

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FISH performed on the decalcified bone marrow core biopsy demonstrated a BCR-ABL1 translocation in 156/200 (78%) of cells. Karyotypic studies were unable to be performed due to lack of growth.

Reverse transcription-polymerase chain reaction (RT-PCR) analysis performed on the peripheral blood was positive for a fusion mRNA transcript arising from a t(9;22)(q34;q11) translocation (e1a2 BCR-ABL1).

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